[HTML][HTML] Pathogenesis of autoimmune disease
DS Pisetsky - Nature Reviews Nephrology, 2023 - nature.com
Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …
and T cell reactivity to normal constituents of the host. These diseases occur widely and …
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
Checkpoint inhibitor-based immunotherapies that target cytotoxic T lymphocyte antigen 4
(CTLA4) or the programmed cell death 1 (PD1) pathway have achieved impressive success …
(CTLA4) or the programmed cell death 1 (PD1) pathway have achieved impressive success …
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
Horizontal pleiotropy occurs when the variant has an effect on disease outside of its effect on
the exposure in Mendelian randomization (MR). Violation of the 'no horizontal …
the exposure in Mendelian randomization (MR). Violation of the 'no horizontal …
From genome-wide associations to candidate causal variants by statistical fine-mapping
Advancing from statistical associations of complex traits with genetic markers to
understanding the functional genetic variants that influence traits is often a complex process …
understanding the functional genetic variants that influence traits is often a complex process …
The role of inflammation and genetics in periodontal disease
BG Loos, TE Van Dyke - Periodontology 2000, 2020 - Wiley Online Library
Periodontitis is a complex disease:(a) various causative factors play a role simultaneously
and interact with each other; and (b) the disease is episodic in nature, and bursts of disease …
and interact with each other; and (b) the disease is episodic in nature, and bursts of disease …
Elements of cancer immunity and the cancer–immune set point
Immunotherapy is proving to be an effective therapeutic approach in a variety of cancers. But
despite the clinical success of antibodies against the immune regulators CTLA4 and PD …
despite the clinical success of antibodies against the immune regulators CTLA4 and PD …
The Parkinson's progression markers initiative (PPMI)–establishing a PD biomarker cohort
K Marek, S Chowdhury, A Siderowf… - Annals of clinical …, 2018 - Wiley Online Library
Abstract Objective The Parkinson's Progression Markers Initiative (PPMI) is an
observational, international study designed to establish biomarker‐defined cohorts and …
observational, international study designed to establish biomarker‐defined cohorts and …
Ankylosing spondylitis and axial spondyloarthritis
JD Taurog, A Chhabra, RA Colbert - New England Journal of …, 2016 - Mass Medical Soc
Ankylosing Spondylitis and Axial Spondyloarthritis | NEJM Skip to main content NEJM Group
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Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to become a physician, build …
[PDF][PDF] Immunometabolic pathways in BCG-induced trained immunity
RJW Arts, A Carvalho, C La Rocca, C Palma… - Cell reports, 2016 - cell.com
The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on
unrelated infections are thought to be mediated by long-term metabolic changes and …
unrelated infections are thought to be mediated by long-term metabolic changes and …
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's
disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate …
disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate …