Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

The WNT signaling pathway is a critical regulator of development and adult tissue
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …

Colorectal cancer (CRC) is one of the most common malignant tumor types occurring in the
digestive system. The incidence of CRC has exhibits yearly increases and the mortality rate …

Considering the indispensable significance and utilities of meta-substituted pyridines in
medicinal, chemical as well as materials science, a direct meta-selective C–H …

Wnt/β-catenin and phosphatidylinositol-3-kinase/protein kinase B/mammalian target of
rapamycin complex 1 (PI3K/AKT/mTORC1) pathways both are critically involved in …

The majority of colorectal cancers show hyperactivated WNT signaling due to inactivating
mutations in the adenomatous polyposis coli (APC) tumor suppressor. Genetically restoring …

Tankyrases are multifunctional poly (adenosine diphosphate-ribose) polymerases that
regulate diverse biological processes including telomere maintenance and cellular …

The cancer stem cell (CSC) state and epithelial-mesenchymal transition (EMT) activation are
tightly interconnected. Cancer cells that acquire the EMT/CSC phenotype are equipped with …

A library of pyridine-based 1, 2, 4-triazolo-tethered indole conjugates were designed,
synthesized, and evaluated for anti-proliferative activity against a panel of six human cancer …

Tankyrase 1 and 2 (TNKS1/2) catalyze post-translational modification by poly-ADP-
ribosylation of a plethora of target proteins. In this function, TNKS1/2 also impact the WNT/β …