Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone Page 1
PHYSIOLOGICAL REVIEWS Vol. 69, No. 3, July 1989 Printed in US.A. Osteocalcin and …

Blood coagulation is a host defense system that assists in maintaining the integrity of the
closed, high-pressure mammalian circulatory system after blood vessel injury. After initiation …

Reports of single base-pair mutations within gene coding regions causing human genetic
disease were collated. Thirty-five per cent of mutations were found to have occurred within …

Previous work demonstrated that human furin is a predominantly Golgi membrane-localized
endoprotease that can efficiently process precursor proteins at paired basic residues (-Lys …

Defects in the gene encoding the endothelin-B receptor produce aganglionic megacolon
and pigmentary disorders in mice and humans. We report that a targeted disruption of the …

Limited endoproteolysis of inactive precursor proteins at sites marked by paired or multiple
basic amino acids is a widespread process by which biologically active peptides and …

Many peptide hormones are produced from larger precursors by endoproteolysis at pairs of
basic amino acids (eg Lys-Arg and Arg-Arg) within the regulated secretory pathway in …

Furin is a membrane‐associated endoprotease that efficiently cleaves precursor proteins on
the C‐terminal side of the consensus sequence, Arg‐X‐Lys/Arg‐Arg1, and has been …

During the last decade our knowledge concerning vitamin K-dependent processes has been
substantially increased, and laboratory techniques have been developed which enable a …

Furin is a secretory pathway endoprotease that catalyses the maturation of a strikingly
diverse group of proprotein substrates, ranging from growth factors and receptors to …