[HTML][HTML] Merkel cell carcinoma: epidemiology, prognosis, therapy and unmet medical needs

D Schadendorf, C Lebbé, A Zur Hausen… - European journal of …, 2017 - Elsevier
Merkel cell carcinoma (MCC) is a rare skin cancer that is associated with Merkel cell
polyomavirus infection in most cases. Incidence rates of MCC have increased in past …

The biology and treatment of Merkel cell carcinoma: current understanding and research priorities

PW Harms, KL Harms, PS Moore… - Nature reviews Clinical …, 2018 - nature.com
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer associated with
advanced age and immunosuppression. Over the past decade, an association has been …

Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy

G Goh, T Walradt, V Markarov, A Blom, N Riaz… - …, 2015 - pmc.ncbi.nlm.nih.gov
Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendocrine
carcinoma, associated with the Merkel cell polyomavirus (MCPyV) in 80% of cases. To …

miRNAs driving diagnosis, prognosis and progression in Merkel cell carcinoma

TM Al-Noshokaty, MS Elballal, GK Helal… - … -Research and Practice, 2023 - Elsevier
Merkel cell carcinoma (MCC) is a rare, aggressive form of skin malignancy with a high
recurrence commonly within two to three years of initial diagnosis. The incidence of MCC …

PD-L1 expression in the Merkel cell carcinoma microenvironment: association with inflammation, Merkel cell polyomavirus, and overall survival

EJ Lipson, JG Vincent, M Loyo, LT Kagohara… - Cancer immunology …, 2013 - AACR
Merkel cell carcinoma (MCC) is a lethal, virus-associated cancer that lacks effective
therapies for advanced disease. Agents blocking the PD-1/PD-L1 pathway have shown …

Merkel cell carcinoma: an update and review: pathogenesis, diagnosis, and staging

K Coggshall, TL Tello, JP North, SY Siegrid - Journal of the American …, 2018 - Elsevier
Merkel cell carcinoma (MCC) is an uncommon primary cutaneous neuroendocrine cancer. It
most commonly presents as an indurated plaque or nodule on sun-damaged skin in elderly …

The genomic landscape of Merkel cell carcinoma and clinicogenomic biomarkers of response to immune checkpoint inhibitor therapy

TC Knepper, M Montesion, JS Russell, ES Sokol… - Clinical Cancer …, 2019 - AACR
Purpose: Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy, which
has demonstrated sensitivity to immune checkpoint inhibitor therapy. Here, we perform the …

[HTML][HTML] Polyomavirus-negative Merkel cell carcinoma: a more aggressive subtype based on analysis of 282 cases using multimodal tumor virus detection

AS Moshiri, R Doumani, L Yelistratova, A Blom… - Journal of Investigative …, 2017 - Elsevier
Previous studies have reached conflicting conclusions regarding the proportion of Merkel
cell carcinomas (MCCs) that contain the Merkel cell polyomavirus (MCPyV) and the clinical …

[HTML][HTML] Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline

C Lebbe, JC Becker, JJ Grob, J Malvehy… - European journal of …, 2015 - Elsevier
Merkel cell carcinoma (MCC) is a rare tumour of the skin of neuro-endocrine origin probably
developing from neuronal mechanoreceptors. A collaborative group of multidisciplinary …

Viral oncology: molecular biology and pathogenesis

UN Mui, CT Haley, SK Tyring - Journal of clinical medicine, 2017 - mdpi.com
Oncoviruses are implicated in approximately 12% of all human cancers. A large number of
the world's population harbors at least one of these oncoviruses, but only a small proportion …