The ubiquitous purine nucleoside phosphorylases (PNPs) play a key role in the purine
salvage pathway, and PNP deficiency in humans leads to an impairment of T-cell function …

The reversible phosphorolysis of purine and pyrimidine nucleosides is an important
biochemical reaction in the salvage pathway, which provides an alternative to the de novo …

PURPOSE: To quantitate and characterize the expression of an engineered human
transferrin receptor (ETR) as a marker gene by using magnetic resonance (MR) imaging …

Standard chemotherapeutic agents and ionizing radiation destroy dividing cells. Because
tumor cells divide more rapidly than normal cells, there is a therapeutic index in which …

AKLLODHDOXZMMG-AKUKZJRUSA-N CC ([C@ H]([C@ H]([C@ H] 1F) O) O [C@ H] 1 [n]
1c (ncnc2N) c2nc1) O Chemical compound CC ([C@ H]([C@ H]([C@ H] 1F) O) O [C@ H] 1 …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
27533273&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

This invention provides methods of obtaining novel polynucleotides and encoded
polypeptides by the use of non-stochastic methods of directed evolution (DirectEvolution™) …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
23300064&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

This invention pertains to the field of genetic vaccines. Specifically, the invention provides
multi-component genetic vaccines that contain components that are optimized for a …

Introduction: High-grade gliomas (HGGs) still have a high rate of recurrence and lethality.
Gene therapies were projected to overcome the therapeutic resilience of HGGs, due to the …