Hepatocytes, the major parenchymal cells in the liver, are responsible for a variety of cellular
functions including carbohydrate, lipid and protein metabolism, detoxification and immune …

Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …

Autoimmune hepatitis (AIH) is a liver disease characterized by chronic liver inflammation.
The intestinal barrier and microbiome play critical roles in AIH progression. AIH treatment …

Off-tumor targeting of human antigens is difficult to predict in preclinical animal studies and
can lead to serious adverse effects in patients. To address this, we developed a mouse …

Simple Summary Intercellular adhesion molecule 1 (ICAM-1) is a protein produced by cells
in blood vessel walls, as well as many other cell types. It localizes to the surface of these …

Background HIV can infect multiple cells in the liver including hepatocytes, Kupffer cells and
infiltrating T cells, but whether HIV can persist in the liver in people with HIV (PWH) on …

Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease
worldwide. Despite extensive research and multiple clinical trials, there are still no FDA …

A phenomenon known for over 100 years named “cell-in-cell”(CIC) is now undergoing its
renaissance, mostly due to modern cell visualization techniques. It is no longer an esoteric …

Entosis is a cell-in-cell (CIC)-mediated death program. Contractile actomyosin (CA) and the
adherens junction (AJ) are two core elements essential for entotic CIC formation, but the …

The presence of CD8+ T cells in the cytoplasm of biliary epithelial cells (BEC) has been
correlated with biliary damage associated with primary biliary cholangitis (PBC). Here, we …