Cytostatic bacterial metabolites interfere with 5-fluorouracil, doxorubicin and paclitaxel efficiency in 4T1 breast cancer cells

S Schwarcz, P Nyerges, TI Bíró, E Janka, P Bai, E Mikó - Molecules, 2024 - mdpi.com
The microbiome is capable of modulating the bioavailability of chemotherapy drugs, mainly
due to metabolizing these agents. Multiple cytostatic bacterial metabolites were recently …

The bacterial metabolite, lithocholic acid, has antineoplastic effects in pancreatic adenocarcinoma

S Schwarcz, P Kovács, P Nyerges, G Ujlaki… - Cell Death …, 2024 - nature.com
Lithocholic acid (LCA) is a secondary bile acid. LCA enters the circulation after bacterial
synthesis in the gastrointestinal tract, reaches distantly located cancer cells, and influences …

[HTML][HTML] Molecular mechanisms of high aldehyde dehydrogenase production for improved beany flavour regulated by the LuxS/AI-2 quorum sensing system in …

Y Chai, C Zi, G Wei, J He, Q Ma, A Huang - LWT, 2024 - Elsevier
Aldehydes cause beany flavor, which is one of the factors limiting the further development of
plant-based fermented milks. Limosilactobacillus fermentum (L. fermentum) A119, which has …

Anticarcinogenic effects of ursodeoxycholic acid in pancreatic adenocarcinoma cell models

P Kovács, S Schwarcz, P Nyerges, TI Bíró… - Frontiers in Cell and …, 2024 - frontiersin.org
Changes to the composition of the microbiome in neoplasia, is termed oncobiosis, may
affect tumor behavior through the changes to the secretion of bacterial metabolites. In this …

Cytostatic Bacterial Metabolites Interfere with 5-Fluorouracil and Paclitaxel Efficiency in 4T1 Breast Cancer Cells

S Schwarcz, P Nyerges, TI Bíró, E Janka, P Bai, E Mikó - 2024 - preprints.org
The microbiome is capable of modulating the bioavailability of chemotherapy drugs mainly
due to metabolizing these agents. Multiple cytostatic bacterial metabolites were recently …

Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human …

M Amrutkar, SJT Guttorm, AV Finstadsveen… - Molecular … - Wiley Online Library
Neoadjuvant chemotherapy (NAT) is increasingly used for the treatment of non‐metastatic
pancreatic ductal adenocarcinoma (PDAC) and is established as a standard of care for …

The bacterial metabolite, lithocholic acid, has antineoplastic effects in pancreatic adenocarcinoma

E Mikó, S Schwarcz, P Kovács, P Nyerges, G Ujlaki… - 2024 - researchsquare.com
Lithocholic acid (LCA) is a secondary bile acid. LCA enters the circulation after bacterial
synthesis in the gastrointestinal tract, reaches distantly located cancer cells, and influences …

Ursodeoxycholic acid prompts glycolytic dominance, reductive stress and epithelial-to-mesenchymal transition in ovarian cancer cells through NRF2 activation

P Bai, A Sipos, É Kerekes, D Szeőcs, F Szarvas… - 2024 - researchsquare.com
Numerous secreted bacterial metabolites were identified with bioactivity in various
neoplasias, including ovarian cancer. One such metabolite is ursodeoxycholic acid (UDCA) …

Identification and Characterization of Bacterial Metabolites with Antineoplastic Activity in Breast Cancer

G Ujlaki - 2024 - search.proquest.com
There is a strong connection between the microbiome and the host. Bacteria residing in
various parts of the human body generate a multitude of bacterial metabolites, which have …

[PDF][PDF] DEBRECEN, 2024

G Ujlaki - dea.lib.unideb.hu
Malignant tumors are complex systemic diseases that result from multiple cellular and
genomic alterations, posing an increasingly severe healthcare problem in Hungary …