Cancer cells are characterized by an increase in the rate of reactive oxygen species (ROS)
production and an altered redox environment compared to normal cells. Furthermore, redox …

NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen
species-generating enzymes that broadly and specifically regulate redox-sensitive …

Background & Aims Pancreatic cancer has the highest prevalence of cancer-associated
cachexia among all cancers. ZIP4 promotes pancreatic cancer progression by regulating …

Dissemination of cancer cells to distant organ sites is the leading cause of death due to
treatment failure in different types of cancer. Mehlen and Puisieux have reviewed the …

Purpose: We tested the hypothesis that allosteric Akt inhibitor MK-2206 inhibits tumor
growth, and that PTEN/PIK3CA mutations confer MK-2206 sensitivity. Experimental Design …

The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key driver in carcinogenesis.
Defects in this pathway in human cancer syndromes such as Cowden's disease and Multiple …

Hepatocellular carcinoma (HCC) is a highly invasive tumor with frequent intrahepatic or
pulmonary metastasis, which is the main reason for high recurrence and poor survival of …

Precise control of the balance between protein phosphorylation, catalyzed by protein
kinases, and protein dephosphorylation, catalyzed by protein phosphatases, is essential for …

Class I phosphoinositide 3-kinase (PI3K) generates phosphatidylinositol 3, 4, 5-
trisphosphate (PtdIns (3, 4, 5) P 3) at the plasma membrane in response to growth factors …

Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …