Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated
as natural byproducts during cellular processes, including metabolism. Under normal …

In most cases, sorafenib-resistant HCC cells exhibit significant mesenchymal phenotype and
stemness features. In this context, tumor cells might undergo cell fate transition in response …

Iron homeostasis is essential for health; moreover, hepcidin-deficiency results in iron
overload in both hereditary hemochromatosis and iron-loading anemia. Here, we identified …

Hepatocellular carcinoma (HCC) invariably exhibits inadequate O2 (hypoxia) and nutrient
supply. Hypoxia-inducible factor (HIF) mediates cascades of molecular events that enable …

Sorafenib is a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC),
but its clinical effects are still limited. In this study we identify Quiescin sulfhydryl oxidase 1 …

Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …

Background Hepatocellular carcinoma (HCC) is among the most common forms of cancer
and is associated with poor patient outcomes. The emergence of therapeutic resistance has …

The nonnegligible reason for the poor prognosis of hepatocellular carcinoma (HCC) is
resistance to conventional chemotherapy. Immunogenic cell death (ICD) is a rare …

Background & Aims Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with
dreadful clinical outcome. Tyrosine kinase inhibitors and immune checkpoint inhibitors are …

Ferroptosis is an atypical form of regulated cell death, which is different from apoptosis,
necrosis, pyroptosis, and autophagy. Ferroptosis is characterized by iron‐dependent …