Hypouricemia is recognized as a rare disorder, defined as a serum uric acid level of 2.0
mg/dL or less. Hypouricemia is divided into an overexcretion type and an underproduction …

We presented an update in the field of hypouricemia, which is defined as a serum urate
concentration of< 2 mg/dL (119 μmol/L), for the practicing rheumatologist, who usually is the …

Elevated serum urate levels can cause gout, an excruciating disease with suboptimal
treatment. Previous GWAS identified common variants with modest effects on serum urate …

Urate is an endogenous product of purine metabolism in the liver. High urate levels in the
blood lead to gout, a very common and painful inflammatory arthritis. Excreted urate is …

Background Renal hypouricemia (RHUC), a rare inherited disorder characterized by
impaired uric acid (UA) reabsorption in the proximal tubule, is caused by mutations in …

The ABCG2 gene is a well-established hyperuricemia/gout risk locus encoding a urate
transporter that plays a crucial role in renal and intestinal urate excretion. Hitherto, p. Q141K …

Background Hereditary renal hypouricemia type 1 (RHUC1) is caused by
URAT1/SLC22A12 dysfunction, resulting in urolithiasis and exercise-induced AKI (EIAKI) …

Renal hypouricemia is a disease caused by the dysfunction of renal urate transporters. This
disease is known to cause exercise-induced acute kidney injury, but its mechanism has not …

Objective Uric acid is the end product of purine metabolism in humans, and increased serum
uric acid concentrations lead to gout. The objective of the current study was to identify factors …

Renal hypouricemia (RHUC) is a pathological condition characterized by extremely low
serum urate and overexcretion of urate in the kidney; this inheritable disorder is classified …