PAR proteins constitute a highly conserved network of scaffolding proteins, adaptors and
enzymes that form and stabilize cortical asymmetries in response to diverse inputs. They …

Having a sense of direction is a fundamental cellular trait that can determine cell shape,
division orientation, or function, and ultimately the formation of a functional, multicellular …

Spontaneous pattern formation in Turing systems relies on feedback. But patterns in cells
and tissues seldom form spontaneously—instead they are controlled by regulatory …

During development, the conserved PAR polarity network is continuously redeployed,
requiring that it adapt to changing cellular contexts and environmental cues. In the early C …

How living systems break symmetry in an organized manner is a fundamental question in
biology. In wild-type Caenorhabditis elegans zygotes, symmetry breaking during anterior …

Reaction–diffusion networks underlie pattern formation in a range of biological contexts,
from morphogenesis of organisms to the polarization of individual cells. One requirement for …

Clustering of membrane-associated molecules is thought to promote interactions with the
actomyosin cortex, enabling sizedependent transport by actin flows. Consistent with this …

The actomyosin cortex regulates the localization and function of proteins at the plasma
membrane. Here, we study how membrane binding, cortical movements, and diffusion …

Molecules inside cells are subject to physical forces and undergo biochemical interactions,
continuously changing their physical properties and dynamics. Despite this, cells achieve …

Protein concentration gradients organize cells and tissues and commonly form through
diffusion away from a local source of protein. Interestingly, during the asymmetric division of …