As a result of the adaptation of life to an aerobic environment, nature has evolved a panoply
of metalloproteins for oxidative metabolism and protection against reactive oxygen species …

Heme-copper oxidases (HCOs) are terminal enzymes on the mitochondrial or bacterial
respiratory electron transport chain, which utilize a unique heterobinuclear active site to …

Celastrol (CEL), an active compound isolated from the root of Tripterygium wilfordii, exhibits
broad anticancer activities. However, its poor stability, narrow therapeutic window and …

Structural regulation of the active centers is often pivotal in controlling the catalytic functions,
especially in iron-based oxidation systems. Here, we discovered a significantly altered …

Catalytic oxidation reactions are pivotal transformations in living creatures and chemical
industries, in which metal-oxygen intermediates, including high-valent metal-oxo species …

Dye-decolorizing peroxidases (DyPs) are a family of microbial heme-containing peroxidases
that show important properties for lignocellulose biorefineries due to their ability to oxidize …

The cytochrome P450 monooxygenases (P450s) are thiolate heme proteins that can, often
under physiological conditions, catalyze many distinct oxidative transformations on a wide …

Establishing redox and thermodynamic relationships between metal-ion-bound O2 and its
reduced (and protonated) derivatives is critically important for a full understanding of (bio) …

Ablation of androgen production through surgery is one strategy against prostate cancer,
with the current focus placed on pharmaceutical intervention to restrict androgen synthesis …

Porphyrin-based chemistry has reached an unprecedented period of rapid development
after decades of study. Due to attractive multifunctional properties, porphyrins and their …