Lung cancer is one of the common forms of cancer that affects both men and women and is
regarded as the leading cause of cancer related deaths. It is characterized by unregulated …

Programmed cell death, in particular apoptosis, is essential during development and tissue
homeostasis, and also is the primary strategy to induce cancer cell death by cytotoxic …

Ginseng (Panax ginseng Meyer) has been used in East Asian traditional medicine for a long
time. Korean red ginseng (KRG) is effective against several disorders, including cancer. The …

The molecular mechanism of apoptosome activation through conformational changes of
Apaf-1 auto-inhibited form remains largely enigmatic. The crystal structure of Apaf-1 …

Apoptosis plays a pivotal role in the immune response to combat pathogen infections. In
mammals, caspase-9, abbreviated as Casp9, plays an irreplaceable role in the initiation …

Multiple myeloma (MM) is a hematological malignancy of plasma cells that produce a
monoclonal immunoglobulin protein. Despite significant advances in the treatment of MM …

Previous evidence revealed significant elevated liver cancer mortality in the areas where
water was contaminated with hexavalent chromium [Cr (vi)], which highlighted that we …

Apoptosis is an important antiviral host defense mechanism. Here we report the
identification of a novel apoptosis inhibitor encoded by the vaccinia virus (VACV) M1L gene …

Recent evidence suggests that mitochondrial apoptosis regulators and executioners may
regulate differentiation, without being involved in cell death. However, the involved factors …

Notwithstanding uncertain pathogenesis of inflammatory bowel disease (IBD), deregulation
of adaptive immunity is paramount for the development of inflammation. Essential role in the …