The cell wall envelopes of gram-positive bacteria represent a surface organelle that not only
functions as a cytoskeletal element but also promotes interactions between bacteria and …

▪ Abstract Integrins are a structurally elaborate family of heterodimers that mediate divalent
cation-dependent cell adhesion in a wide range of biological contexts. The inserted (I) …

Type I collagen is the most abundant protein in humans, and it helps to maintain the integrity
of many tissues via its interactions with cell surfaces, other extracellular matrix molecules …

We have determined the crystal structure of a complex between the I domain of integrin
α2β1 and a triple helical collagen peptide containing a critical GFOGER motif. Three loops …

Among adhesion receptor families, integrins are particularly important in biological
processes that require rapid modulation of adhesion and de‐adhesion. Activation on a …

The structural basis for the association of eukaryotic and prokaryotic protein receptors and
their triple‐helical collagen ligand remains poorly understood. Here, we present the crystal …

Members of a family of collagen-binding microbial surface components recognizing
adhesive matrix molecules (MSCRAMMs) from Gram-positive bacteria are established …

Integrins α 1 β 1 and α 2 β 1 are two major collagen receptors on the surface of eukaryotic
cells. Binding to collagen is primarily due to an A-domain near the N terminus of the α …

Visualization of the formation and orientation of collagen fibers in tissue engineering
experiments is crucial for understanding the factors that determine the mechanical …

ABSTRACT Group A Streptococcus (GAS) expresses cell surface proteins that mediate
important biological functions such as resistance to phagocytosis, adherence to plasma and …