Autoimmune pre-disease

K Bieber, JE Hundt, X Yu, M Ehlers, F Petersen… - Autoimmunity …, 2023 - Elsevier
Approximately 5% of the world-wide population is affected by autoimmune diseases.
Overall, autoimmune diseases are still difficult to treat, impose a high burden on patients …

Systematic review of deep learning image analyses for the diagnosis and monitoring of skin disease

SP Choy, BJ Kim, A Paolino, WR Tan, SML Lim… - NPJ Digital …, 2023 - nature.com
Skin diseases affect one-third of the global population, posing a major healthcare burden.
Deep learning may optimise healthcare workflows through processing skin images via …

Therapeutic strategies for oral lichen planus: State of the art and new insights

D Didona, RD Caposiena Caro… - Frontiers in …, 2022 - frontiersin.org
Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa. Several
clinical subtypes of OLP have been reported, including the reticular and erosive one. On the …

Comprehensive insight into lichen planus immunopathogenesis

M Vičić, N Hlača, M Kaštelan, I Brajac… - International Journal of …, 2023 - mdpi.com
Lichen planus is a chronic disease affecting the skin, appendages, and mucous
membranes. A cutaneous lichen planus is a rare disease occurring in less than 1% of the …

Regulating size and charge of liposomes in microneedles to enhance intracellular drug delivery efficiency in skin for psoriasis therapy

F Qu, Y Sun, D Bi, S Peng, M Li, H Liu… - Advanced …, 2023 - Wiley Online Library
The stratum corneum (SC) and cell membrane are two major barriers that hinder the
therapeutic outcomes of transdermal drug delivery for the treatment of skin diseases. While …

Hidradenitis suppurativa: a perspective on genetic factors involved in the disease

C Moltrasio, PM Tricarico, M Romagnuolo, AV Marzano… - Biomedicines, 2022 - mdpi.com
Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease of the pilosebaceous
unit, clinically consisting of painful nodules, abscesses, and sinus tracts mostly in, but not …

[HTML][HTML] Tapinarof validates the aryl hydrocarbon receptor as a therapeutic target: A clinical review

JI Silverberg, M Boguniewicz, FJ Quintana… - Journal of Allergy and …, 2024 - Elsevier
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that has wide-
ranging roles, including regulation of inflammation and homeostasis. AhR is not a cell …

The regulatory T cell-selective interleukin-2 receptor agonist rezpegaldesleukin in the treatment of inflammatory skin diseases: two randomized, double-blind, placebo …

JI Silverberg, D Rosmarin, R Chovatiya… - Nature …, 2024 - nature.com
Regulatory T cell (Treg) impairment is implicated in the pathogenesis of chronic
inflammatory diseases, but relatively little is known about the therapeutic potential of Treg …

Impact of pretreatment systemic inflammatory markers on treatment persistence with biologics and conventional systemic therapy: a retrospective study of patients with …

E Sugimoto, H Matsuda, S Shibata, Y Mizuno… - Journal of Clinical …, 2023 - mdpi.com
Systemic inflammation plays a central role in the pathophysiology of psoriasis. This study
examined accessible systemic inflammatory markers in patients with psoriasis vulgaris and …

Hidradenitis suppurativa: new insights into disease mechanisms and an evolving treatment landscape

JG Krueger, J Frew, GBE Jemec… - British Journal of …, 2024 - academic.oup.com
Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic disabling and
debilitating inflammatory disease with a high unmet medical need. The prevalence of HS …