Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …

Objective: To evaluate the association between diagnosis of Parkinson disease (PD) and
risk factors or early symptoms amenable to population‐based screening. Methods: A …

Parkinson's disease (PD) is a progressive neurodegenerative disorder, which is
characterised by degeneration of distinct neuronal populations, including dopaminergic …

Increasing recognition that Parkinson's disease (PD) may start outside of the substantia
nigra has led to a rapidly expanding effort to define prodromal stages of PD, before motor …

Recent investigation into the mechanisms of Parkinson's disease (PD) has generated
remarkable insight while simultaneously challenging traditional conceptual frameworks …

Parkinson's disease is a neurodegenerative process characterized by numerous motor and
nonmotor clinical manifestations for which effective, mechanism-based treatments remain …

It is reasonably well established that prior to the motor phase of classical Parkinson's
disease (PD) there is a prodromal period of several years duration. Once typical motor …

Parkinson's disease (PD) is recognized by the accumulation of α-synuclein within neurons.
In contrast to the current ascending theory where α-synuclein would propagate from neuron …

Objective: To investigate the long-term risk of Parkinson disease (PD) after depression and
evaluate potential confounding by shared susceptibility to the 2 diagnoses. Methods: The …

Physical exercise has been associated with neuroprotective effects in the nigrostriatal
dopaminergic system. To examine the impact of physical activity on Parkinson's disease risk …