Decreases in the costs of high-throughput sequencing technologies have led to continually
increasing numbers of livestock RNA-Seq studies in the last decade. Although the number of …

Background This paper reviews the localization of published potential causative variants in
contemporary pig and cattle reference genomes, and the evidence for their causality. In spite …

Background Characterization of the molecular mechanisms underlying hair follicle
development is of paramount importance in the genetic improvement of wool-related traits in …

In addition to their common usages to study gene expression, RNA-seq data accumulated
over the last 10 years are a yet-unexploited resource of SNPs in numerous individuals from …

Background Causal variants for complex traits, such as eQTL are often found in non-coding
regions of the genome, where they are hypothesised to influence phenotypes by regulating …

Many quantitative trait loci (QTLs) are in non-coding regions. Therefore, QTLs are assumed
to affect gene regulation. Gene expression and RNA splicing are primary steps of …

The branch point sequence is a cis-acting intronic motif required for mRNA splicing. Despite
their functional importance, branch point sequences are not routinely annotated. Here we …

Despite the clear potential of livestock models of human functional variants to provide
important insights into the biological mechanisms driving human diseases and traits, their …

The hypothalamic-pituitary-gonad (HPG) axis is vital for reproductive activities in vertebrates.
The large-scale comparative analyses of gene expression in the HPG axis across …

Runs of heterozygosity (ROHet) and homozygosity (ROH) harbor useful information related
to traits of interest. There is a lack of investigating the effect of ROHet and ROH on …