Structural malformations of the brain are an important cause of childhood mortality and
morbidity, with the latter having long-term financial and psychosocial implications for the …

Holoprosencephaly (HPE) is a complex congenital brain malformation characterized by
failure of the forebrain to bifurcate into two hemispheres, a process normally completed by …

Background: The middle interhemispheric variant (MIH) is a subtype of holoprosencephaly
(HPE) in which the posterior frontal and parietal areas lack midline separation, whereas …

Recent advances in genetics and neuroimaging have greatly contributed to our
understanding of the spectrum of midline brain and craniofacial malformations known as …

Hypotheses are presented to explain the pathogenesis of several clinical features of
holoprosencephaly, and neuropathologic approaches to testing these hypotheses are …

HPE is a congenital brain malformation characterized by failure of the prosencephalon to
divide into 2 hemispheres. We have identified 7 patients who have a mild subtype of HPE in …

Holoprosencephaly is a spectrum of congenital defects of forebrain development
characterized by incomplete separation of the cerebral hemispheres. In vivo diagnosis can …

Magnetic resonance imaging has undergone dramatic development in the past years. This
has been paralleled by developments in the tools for extracting quantitative information from …

Brain malformations are extremely polymorphous, and individual cases very often escape
rigid categorization. Moreover, several malformations are frequently associated with one …

PURPOSE: To evaluate the dimensions of specific white matter tracts in the brainstems
(region of brain thought to be least affected) of children with holoprosencephaly by using …