Evolutionary diversity and function of metacaspases in plants: similar to but not caspases

SU Huh - International Journal of Molecular Sciences, 2022 - mdpi.com
Caspase is a well-studied metazoan protease involved in programmed cell death and
immunity in animals. Obviously, homologues of caspases with evolutionarily similar …

The role of cytokines in cholesterol accumulation in cells and atherosclerosis progression

AM Markin, YV Markina, AI Bogatyreva… - International Journal of …, 2023 - mdpi.com
Atherosclerosis is the most common cardiovascular disease and is the number one cause of
death worldwide. Today, atherosclerosis is a multifactorial chronic inflammatory disease with …

A novel BH3 mimetic Bcl-2 inhibitor promotes autophagic cell death and reduces in vivo Glioblastoma tumor growth

S Calis, B Dogan, S Durdagi, A Celebi, O Yapicier… - Cell Death …, 2022 - nature.com
Anti-apoptotic members of the Bcl-2 family proteins play central roles in the regulation of cell
death in glioblastoma (GBM), the most malignant type of brain tumor. Despite the advances …

Caspases help to spread the message via extracellular vesicles

C Hill, ER Dellar, LA Baena‐Lopez - The FEBS Journal, 2023 - Wiley Online Library
Cell‐cell communication is an essential aspect of multicellular life, key for coordinating cell
proliferation, growth, and death in response to environmental changes. Whilst caspases are …

[HTML][HTML] Chamaecyparis lawsoniana Leaf Essential Oil as a Potential Anticancer Agent: Experimental and Computational Studies

E Fikry, R Orfali, SS Elbaramawi, S Perveen… - Plants, 2023 - mdpi.com
Cancer remains one of the leading causes of death worldwide, affected by several factors
including oxidative stress; and although conventional synthetic medicines have been used …

Shedding new light on methylmercury-induced neurotoxicity through the crosstalk between autophagy and apoptosis

L Ni, Y Wei, J Pan, X Li, B Xu, Y Deng, T Yang, W Liu - Toxicology letters, 2022 - Elsevier
Methylmercury (MeHg) is a bio-accumulative global environmental contaminant present in
fish and seafood. MeHg accumulates in the aquatic environment and eventually reaches the …

Antiproliferative Effect of Gallic Acid is Mediated via Mitochondrial‐or ER‐Stress‐Induced Apoptosis and Canonical Autophagy in HT‐29 Cells

J Shao, L Yang, Z Jin, Y Bao, J He, QH Le… - Journal of …, 2024 - Wiley Online Library
Cancer is a noncommunicable disease burden and the second‐leading cause of death
worldwide. Novel medications and drug possibilities are sought everyday throughout the …

The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?

K Seyrek, F Wohlfromm, J Espe, IN Lavrik - Biochemical Journal, 2022 - portlandpress.com
Breast cancer is still the most common cancer in women worldwide. Resistance to drugs and
recurrence of the disease are two leading causes of failure in treatment. For a more efficient …

Fabrication and physicochemical characterization of copper oxide–pyrrhotite nanocomposites for the cytotoxic effects on HepG2 cells and the mechanism

Y He, H Huang, M Fan, Z Wang, X Liu… - Nanotechnology …, 2023 - degruyter.com
Abstract Novel CuO–FeS nanocomposites were synthesized to exert anticancer effects on
HepG2 cells. The formation was initially demonstrated using UV–Visible spectrophotometry …

[HTML][HTML] Itaconic Acid as A Differential Transcription Regulator of Apoptosis and Autophagy Pathways Genes: A Rat Adipose Mesenchymal Stem Cells Model

MR Tabandeh, F Soroush, D Dayer - Cell Journal (Yakhteh), 2022 - ncbi.nlm.nih.gov
Objective Itaconate, a novel regulatory immunometabolite, is synthesized by inflammatory
macrophage. It acts as an anti-inflammatory mediator and regulates several metabolic and …