Glioblastoma is the most common malignant primary brain tumor in adults and is almost
invariably fatal. Despite our growing understanding of the various mechanisms underlying …

Background Patients with metastatic breast cancer (MBC) are living longer, but the
development of brain metastases often limits their survival. We conducted a systematic …

The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in
the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers …

Cells of glioblastoma, the most frequent primary malignant brain tumor, are characterized by
their rapid growth and infiltration of adjacent healthy brain parenchyma, which reflects their …

The tumor microenvironment (TME), which includes both cellular and non-cellular elements,
is now recognized as one of the major regulators of the development of primary tumors, the …

Simple Summary Leptomeningeal metastases are a devastating complication of solid
tumors with poor survival, regardless of the type of treatments. The limited efficacy of …

Remarkable progress in breast cancer treatment has improved patient survival, resulting in
an increased incidence of brain metastasis (BM). Current treatment options for BM are …

The management of breast cancer (BC) has rapidly evolved in the last 20 years. The
improvement of systemic therapy allows a remarkable control of extracranial disease …

Background Disruption of cell‐cycle regulators is a potential therapeutic target for brain
tumors in children and adolescents. The aim of this study was to determine the maximum …

Brain tumors represent the second most common cause of pediatric cancer death, with
malignant gliomas accounting for∼ 75% of pediatric deaths. Palbociclib, a selective cyclin …