Blood vessels are critical to deliver oxygen and nutrients to tissues and organs throughout
the body. The blood vessels that vascularize the central nervous system (CNS) possess …

Structural and functional integrity of the cerebral vasculature ensures proper brain
development and function, as well as healthy aging. The inability of the brain to store energy …

Claudin-5 is the dominant tight junction protein in brain endothelial cells and exclusively
limits the paracellular permeability of molecules larger than 400 Da across the blood–brain …

Neuroimmune dysregulation is implicated in neuropsychiatric disorders including
schizophrenia. As the blood− brain barrier is the immunological interface between the brain …

In some patients with SZ, a vulnerable brain endothelium may be interacting with
environmental stressors, such as inflammation or hypoxia, converging into a more severe SZ …

The neurovascular unit (NVU) consists of neurons, glial cells, microvascular cells, and
extracellular matrix, and is involved in a variety of physiological and pathological processes …

Claudin-5 is one of the most essential tight junction proteins at the blood-brain barrier. A
single nucleotide polymorphism rs10314 is located in the 3'-untranslated region of claudin-5 …

Purpose This research aimed to investigate serum Zonula occludens-1 (ZO-1) and Claudin-
5 (CLDN5) levels to show whether or not their eventual changes in patients with insomnia …

Abstract 22q11. 2 deletion syndrome (22q11. 2DS) is characterised by high rates of
psychotic disorders and immune abnormalities. Blood–brain barrier (BBB) permeability is …

We present a case study of a young male with a history of 22q11. 2 deletion syndrome
(22qDS), diagnosed with systemic capillary leak syndrome (SCLS) who presented with …