High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple
functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone …

Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …

Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …

Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

Epigenetic changes are present in many physiological and pathological processes. The N 6-
methyladenosine (m6A) modification is the most common modification in eukaryotic mRNA …

Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide and the
single strongest predictor of mortality in patients with diabetes. DKD is a prototypical disease …

Podocytes maintain the glomerular filtration barrier, and the stability of this barrier depends
on their highly differentiated postmitotic phenotype, which also defines the particular …

Kidney fibrosis is a common histological manifestation of functional decline in the kidney.
Fibrosis is a reactive process that develops in response to excessive epithelial injury and …

Podocyte injury is a major determinant of proteinuric kidney disease and the identification of
potential therapeutic targets for preventing podocyte injury has clinical importance. Here, we …

Diabetic nephropathy is one of the leading causes of end‐stage renal disease and creates
heavy healthcare burdens globally. Dysfunction of mesangial cells and podocytes …