Ox-inflammasome involvement in neuroinflammation
Neuroinflammation plays a crucial role in the onset and the progression of several
neuropathologies, from neurodegenerative disorders to migraine, from Rett syndrome to …
neuropathologies, from neurodegenerative disorders to migraine, from Rett syndrome to …
[HTML][HTML] From Plaques to Pathways in Alzheimer's Disease: The Mitochondrial-Neurovascular-Metabolic Hypothesis
S Kazemeini, A Nadeem-Tariq, R Shih… - International Journal of …, 2024 - mdpi.com
Alzheimer's disease (AD) presents a public health challenge due to its progressive
neurodegeneration, cognitive decline, and memory loss. The amyloid cascade hypothesis …
neurodegeneration, cognitive decline, and memory loss. The amyloid cascade hypothesis …
Tetrabromobisphenol A induces neuronal cytotoxicity by inhibiting PINK1-Parkin-mediated mitophagy via upregulating ATF3 expression
X Chao, D Yao, C Chen, Z Sheng, B Zhu - Science of The Total …, 2024 - Elsevier
Tetrabromobisphenol A (TBBPA), as a widely used brominated flame retardant, has been
implicated as a potential neurotoxicant. However, the mechanism of TBBPA-induced …
implicated as a potential neurotoxicant. However, the mechanism of TBBPA-induced …
Honokiol relieves hippocampal neuronal damage in Alzheimer's disease by activating the SIRT3‐mediated mitochondrial autophagy
H Li, J Sun, Y Wu, Y Yang, W Zhang… - CNS neuroscience & …, 2024 - Wiley Online Library
Background This work elucidated the effect of honokiol (HKL) on hippocampal neuronal
mitochondrial function in Alzheimer's disease (AD). Methods APP/PS1 mice were used as …
mitochondrial function in Alzheimer's disease (AD). Methods APP/PS1 mice were used as …
Mitochondrial Complex I and β-Amyloid Peptide Interplay in Alzheimer's Disease: A Critical Review of New and Old Little Regarded Findings
Alzheimer's disease (AD) is the most common neurodegenerative disorder and the main
cause of dementia which is characterized by a progressive cognitive decline that severely …
cause of dementia which is characterized by a progressive cognitive decline that severely …
PGC-1a mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration
W You, K Knoops, TTJM Berendschot… - Cell Death …, 2024 - nature.com
Neurodegenerative disorders are characterized by the progressive loss of structure and
function of neurons, often including the death of the neuron. Previously, we reported that, by …
function of neurons, often including the death of the neuron. Previously, we reported that, by …
The Interplay of Mitochondrial Bioenergetics and Dopamine Agonists as an Effective Disease-Modifying Therapy for Parkinson's Disease
Neha, I Mazahir, SA Khan, P Kaushik, S Parvez - Molecular Neurobiology, 2024 - Springer
Parkinson's disease (PD) is a progressive neurological ailment with a slower rate of
advancement that is more common in older adults. The biggest risk factor for PD is getting …
advancement that is more common in older adults. The biggest risk factor for PD is getting …
Human neural stem cells promote mitochondrial genesis to alleviate neuronal damage in MPTP-induced cynomolgus monkey models
Y He, R Li, Y Yu, C Huang, Z Xu, T Wang… - Neurochemistry …, 2024 - Elsevier
Currently, there is no effective treatment for Parkinson's disease (PD), and the regenerative
treatment of neural stem cells (NSCs) is considered the most promising method. This study …
treatment of neural stem cells (NSCs) is considered the most promising method. This study …
Mitostasis in age-associated neurodegeneration
M Panda, M Markaki, N Tavernarakis - Biochimica et Biophysica Acta (BBA) …, 2024 - Elsevier
Mitochondria are essential organelles that play crucial roles in various metabolic and
signalling pathways. Proper neuronal function is highly dependent on the health of these …
signalling pathways. Proper neuronal function is highly dependent on the health of these …
Deficiency of aldehyde dehydrogenase 2 aggravates ethanol-induced cytotoxicity in N2a cells via CaMKII/Drp1-mediated mitophagy
T Yan, J Chen, Y Wang, Y Wang, Y Zhang… - Food and Chemical …, 2023 - Elsevier
Chronic alcohol abuse causes brain damage and has been associated with an increased
risk of Alzheimer's disease. The toxic metabolite of alcohol, acetaldehyde, which is …
risk of Alzheimer's disease. The toxic metabolite of alcohol, acetaldehyde, which is …