Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Autophagy is a conserved process that catabolizes intracellular components to maintain
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …

Macroautophagy is a major intracellular degradation process recognized as playing a
central role in cell survival and longevity. This multistep process is extensively regulated at …

Autophagy is an evolutionally conserved cytoplasmic degradation system in which varieties
of materials are sequestered by a double membrane structure, autophagosome, and …

Although a budding yeast culture can be propagated eternally, individual yeast cells age
and eventually die. The detailed knowledge of this unicellular eukaryotic species as well as …

Model organisms have played an important role in the elucidation of multiple genes and
cellular processes that regulate aging. In this study we utilized the budding yeast …

Autophagy is a cytoplasmic catabolic process that protects the cell against stressful
conditions. Damaged cellular components are funneled by autophagy into the lysosomes …

Interconnectivity and feedback control are hallmarks of biological systems. This includes
communication between organelles, which allows them to function and adapt to changing …

Objectives: Autophagy is a highly regulated process that has an important role in the control
of a wide range of cellular functions, such as organelle recycling, nutrient availability and …

Recently, efforts have been made to characterize the hallmarks that accompany and
contribute to the phenomenon of aging, as most relevant for humans 1. Remarkably …