Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes
related to learning and memory. The expression of BDNF is highly regulated, and can lead …

Significant progress has been made in understanding the neurobiological mechanisms
through which exercise protects and restores the brain. In this feature review, we integrate …

Physical activity plays an essential role in maintaining a healthy body, yet it also provides
unique benefits for the vascular and cellular systems that sustain a healthy brain. While the …

Late adulthood is associated with increased hippocampal atrophy and dysfunction. Although
there are multiple paths by which hippocampal deterioration occurs in late life, the authors …

Background: Inflammation is linked to cognitive decline in midlife, but the neural basis for
this link is unclear. One possibility is that inflammation associates with adverse changes in …

Neurotrophins, including brain-derived neurotrophic factor (BDNF), are expressed in the
hippocampus, as well as their precursors, the pro-neurotrophins. The neurotrophins signal …

Neurotrophins are essential for multiple aspects of neuronal development and function.
Especially BDNF (brain-derived-neurotrophic-factor) has been shown to play an important …

With the advancement of in vivo studies and clinical trials, the pathogenesis of
neurodegenerative diseases has been better understood. However, gaps still need to be …

Biologists long believed that, once development is completed, no new neurons are
produced in the forebrain. However, as is now firmly established, new neurons can be …

The fine tuning of neural networks during development and learning relies upon both
functional and structural plastic processes. Changes in the number as well as in the size and …