Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches
F Dietlein, L Thelen, HC Reinhardt - Trends in genetics, 2014 - cell.com
Defects in DNA repair pathways enable cancer cells to accumulate genomic alterations that
contribute to their aggressive phenotype. However, tumors rely on residual DNA repair …
contribute to their aggressive phenotype. However, tumors rely on residual DNA repair …
A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response
Repair of DNA double-strand breaks is critical to genomic stability and the prevention of
developmental disorders and cancer. A central pathway for this repair is homologous …
developmental disorders and cancer. A central pathway for this repair is homologous …
[HTML][HTML] Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling
Nephronophthisis-related ciliopathies (NPHP-RC) are degenerative recessive diseases that
affect kidney, retina, and brain. Genetic defects in NPHP gene products that localize to cilia …
affect kidney, retina, and brain. Genetic defects in NPHP gene products that localize to cilia …
[HTML][HTML] Exon-mediated activation of transcription starts
A Fiszbein, KS Krick, BE Begg, CB Burge - Cell, 2019 - cell.com
The processing of RNA transcripts from mammalian genes occurs in proximity to their
transcription. Here, we describe a phenomenon affecting thousands of genes that we call …
transcription. Here, we describe a phenomenon affecting thousands of genes that we call …
A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1
M Blasius, JV Forment, N Thakkar, SA Wagner… - Genome biology, 2011 - Springer
Background The cell-cycle checkpoint kinase Chk1 is essential in mammalian cells due to
its roles in controlling processes such as DNA replication, mitosis and DNA-damage …
its roles in controlling processes such as DNA replication, mitosis and DNA-damage …
Post-transcriptional RNA regulons affecting cell cycle and proliferation
JG Blackinton, JD Keene - Seminars in cell & developmental biology, 2014 - Elsevier
The cellular growth cycle is initiated and maintained by punctual, yet agile, regulatory events
involving modifications of cell cycle proteins as well as coordinated gene expression to …
involving modifications of cell cycle proteins as well as coordinated gene expression to …
A pleiotropic RNA-binding protein controls distinct cell cycle checkpoints to drive resistance of p53-defective tumors to chemotherapy
In normal cells, p53 is activated by DNA damage checkpoint kinases to simultaneously
control the G1/S and G2/M cell cycle checkpoints through transcriptional induction of p21 …
control the G1/S and G2/M cell cycle checkpoints through transcriptional induction of p21 …
MicroRNAs in the DNA damage/repair network and cancer
A Tessitore, G Cicciarelli, F Del Vecchio… - … journal of genomics, 2014 - Wiley Online Library
Cancer is a multistep process characterized by various and different genetic lesions which
cause the transformation of normal cells into tumor cells. To preserve the genomic integrity …
cause the transformation of normal cells into tumor cells. To preserve the genomic integrity …
The emerging role of pre-messenger RNA splicing in stress responses: sending alternative messages and silent messengers
M Dutertre, G Sanchez, J Barbier, L Corcos… - RNA biology, 2011 - Taylor & Francis
Alternative splicing (AS) of pre-messenger RNAs is a major process contributing to both
transcriptome and proteome diversity in various physiological and pathological situations …
transcriptome and proteome diversity in various physiological and pathological situations …