Structural insight into TRPV5 channel function and modulation

S Dang, MK Van Goor, D Asarnow… - Proceedings of the …, 2019 - National Acad Sciences
TRPV5 (transient receptor potential vanilloid 5) is a unique calcium-selective TRP channel
essential for calcium homeostasis. Unlike other TRPV channels, TRPV5 and its close …

Functional Insights into Protein Kinase A (PKA) Signaling from C. elegans

F Sadeghian, PG Castaneda, MR Amin, EJ Cram - Life, 2022 - mdpi.com
Protein kinase A (PKA), which regulates a diverse set of biological functions downstream of
cyclic AMP (cAMP), is a tetramer consisting of two catalytic subunits (PKA-C) and two …

Calmodulin regulates TRPV5 intracellular trafficking and plasma membrane abundance

M Zuidscherwoude, T Grigore… - The Journal of …, 2024 - Wiley Online Library
As a member of the transient receptor potential (TRP) superfamily of ion channels, TRPV5 is
a unique Ca2+‐selective channel important for active reabsorption of Ca2+ in the kidney …

Gα/GSA-1 works upstream of PKA/KIN-1 to regulate calcium signaling and contractility in the Caenorhabditis elegans spermatheca

PG Castaneda, AD Cecchetelli, HN Pettit… - PLoS genetics, 2020 - journals.plos.org
Correct regulation of cell contractility is critical for the function of many biological systems.
The reproductive system of the hermaphroditic nematode C. elegans contains a contractile …

[图书][B] Elucidating Regulatory Mechanisms of Cardiac CaV1. 2 and NaV1. 5 Channels

DD Roybal - 2021 - search.proquest.com
In the heart, sodium (Na+) influx via NaV1. 5 channels initiates the action potential, and
calcium (Ca 2+) influx via CaV1. 2 channels has a key role in excitation-contraction coupling …

G-protein and Protein kinase A signaling networks control contractility and calcium signaling in the Caenorhabditis elegans spermatheca

PG Castaneda - 2021 - search.proquest.com
Correct regulation of contractility and dilation in biological tubes is critical for the function of
the reproductive, cardiovascular, and other systems. Dysregulation of the signaling networks …

TRP Channels in Renal Epithelia

VN Tomilin, O Zaika, O Pochynyuk - … and Ion Channels: Ion Channels and …, 2020 - Springer
Invariability of the internal milieu of the body is essential for normal physiology. Kidneys are
imperative for systemic homeostasis and blood pressure control by tuning water-solute …