Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease

M Jakaria, AA Belaidi, AI Bush… - Journal of …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases

G Tardiolo, P Bramanti, E Mazzon - Molecules, 2018 - mdpi.com
N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific
interest for decades due to its important medical applications. It also represents a nutritional …

N‐acetylcysteine: a review of clinical usefulness (an old drug with new tricks)

GK Schwalfenberg - Journal of nutrition and metabolism, 2021 - Wiley Online Library
Objective. To review the clinical usefulness of N‐acetylcysteine (NAC) as treatment or
adjunctive therapy in a number of medical conditions. Use in Tylenol overdose, cystic …

N-Acetylcysteine (NAC): Impacts on Human Health

MCS Tenório, NG Graciliano, FA Moura, ACM Oliveira… - Antioxidants, 2021 - mdpi.com
N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …

Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: a randomised, double-blinded, placebo-controlled phase-II trial

B Yulug, O Altay, X Li, L Hanoglu, S Cankaya… - Translational …, 2023 - Springer
Background Alzheimer's disease (AD) is associated with metabolic abnormalities linked to
critical elements of neurodegeneration. We recently administered combined metabolic …

Ferroptosis: A potential therapeutic target for neurodegenerative diseases

D Vitalakumar, A Sharma… - Journal of Biochemical …, 2021 - Wiley Online Library
Ferroptosis is a newly identified regulated form of cell death, which is thought to play a major
role in neurodegenerative diseases. In this review, we discuss recent studies elucidating the …

Design, development and in-vitro/in-vivo evaluation of intranasally delivered Rivastigmine and N-Acetyl Cysteine loaded bifunctional niosomes for applications in …

P Kulkarni, D Rawtani, T Barot - European journal of pharmaceutics and …, 2021 - Elsevier
The present investigation explores the potential of novel dual drug-loaded niosomes for
nasal delivery of Rivastigmine (RIV) and N-Acetyl Cysteine (NAC) to the brain. The dual …

Spotlight on ferroptosis: iron-dependent cell death in Alzheimer's disease

A Ashraf, PW So - Frontiers in aging neuroscience, 2020 - frontiersin.org
Alzheimer's disease is an emerging global epidemic that is becoming increasingly
unsustainable. Most of the clinical trials have been centered around targeting β-amyloid and …

Small molecule modulators of alpha-synuclein aggregation and toxicity: Pioneering an emerging arsenal against Parkinson's disease

IA Ahanger, TA Dar - Ageing Research Reviews, 2024 - Elsevier
Parkinson's disease (PD) is primarily characterized by loss of dopaminergic neurons in the
substantia nigra pars compacta region of the brain and accumulation of aggregated forms of …

Cognitive improvement with glutathione supplement in Alzheimer's disease: a way forward

PK Mandal, D Shukla, M Tripathi… - Journal of Alzheimer's …, 2019 - content.iospress.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting millions of
people worldwide. The actual cause of AD is still unknown. Oxidative stress is believed to be …