Depending on the stage of their intervention with the viral replicative cycle, human
immunodeficiency virus inhibitors could be divided into the following groups:(i) adsorption …

Infection by the human immunodeficiency virus type 1 (HIV-1) is an ordered, multistep
process involving binding and entry, reverse transcription, integration, viral gene …

The quinoline U-78036 represents a new class of non-nucleoside human immunodeficiency
virus (HIV)-1 reverse transcriptase inhibitors. The agent possesses excellent antiviral activity …

MATERIALS AND METHODS The expression of HIV-1 RT and its purification have been
described (Deibel et al., 1990; Chattopadhyay et al., 1992). The enzyme was devoid of …

The multifunctional HIV-1 RT (human immunodeficiency virus type 1-reverse transcriptase)
enzyme possesses three main functions including the RNA-and DNA-directed DNA …

ABSTRACT A human cervical explant culture was utilized for the preclinical assessment of
anti-human immunodeficiency virus type 1 (HIV-1) activity and tissue toxicity of formulated …

PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with
nanomolar affinity and block binding of gp120. Both have activity against human …

ABSTRACT A standardized protocol was used to compare cellular toxicities and anti-human
immunodeficiency virus type 1 (HIV-1) activities of candidate microbicides formulated for …

A human colorectal explant culture was developed to assess the safety and efficacy of
topical microbicides proposed for use in humans. Because any product marketed for vaginal …

U-31,355, or 4-amino-2-(benzylthio)-6-chloropyrimidine is an inhibitor of human
immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and possesses anti-HIV …