Significant improvements have been achieved in cardiac arrest resuscitation and postarrest
resuscitation care, but mortality remains high. Most of the poor outcomes and deaths of …

Cardiac arrest effectiveness trials have traditionally reported outcomes that focus on
survival. A lack of consistency in outcome reporting between trials limits the opportunities to …

Background Moderate therapeutic hypothermia is currently recommended to improve
neurologic outcomes in adults with persistent coma after resuscitated out-of-hospital cardiac …

Importance Previous trials have suggested that vasopressin and methylprednisolone
administered during in-hospital cardiac arrest might improve outcomes. Objective To …

Background The effect of bystander interventions on long-term functional outcomes among
survivors of out-of-hospital cardiac arrest has not been extensively studied. Methods We …

Cardiac arrest systems of care are successfully coordinating community, emergency medical
services, and hospital efforts to improve the process of care for patients who have had a …

Background Among cardiac arrest survivors, about half remain comatose 72 h following
return of spontaneous circulation (ROSC). Prognostication of poor neurological outcome in …

Hypoxic–ischaemic brain injury (HIBI) is the main cause of death in patients who are
comatose after resuscitation from cardiac arrest. A poor neurological outcome—defined as …

Background: Neuron-specific enolase (NSE) is a widely-used biomarker for prognostication
of neurological outcome after cardiac arrest, but the relevance of recommended cutoff …

Objectives To review and update the evidence on predictors of poor outcome (death,
persistent vegetative state or severe neurological disability) in adult comatose survivors of …