The dynamic interactions of cancer cells with their microenvironment consisting of stromal
cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to …

The discovery of RNA interference, first in plants and Caenorhabditis elegans and later in
mammalian cells, led to the emergence of a transformative view in biomedical research …

Inducing destruction of specific mRNA using small interfering RNA (siRNA) is a powerful tool
in analysis of protein function, but its use as a therapeutic modality has been limited by …

High-grade prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely
preinvasive stage of adenocarcinoma, almost two decades after its first formal description …

Elevated levels of protein tyrosine phosphorylation contribute to a malignant phenotype,
although the tyrosine kinases that are responsible for this signaling remain largely unknown …

Importance of the field: High mortality rates with cancers warrant further development of
earlier diagnostics and better treatment strategies. Membrane-bound erythropoietin …

Background: Eph receptors and their ligands, the ephrins, represent a large class of cell–cell
communication molecules with well-defined developmental functions. Their role in healthy …

The Eph receptor tyrosine kinases and ephrin ligands have been studied extensively for
their roles in developmental processes. In recent years, Eph receptors and ephrins have …

Eph receptor tyrosine kinases and their ephrin ligands have been implicated in embryonic
vascular development and in in vivo models of angiogenesis. Eph proteins may also …

Interactions between Eph receptor tyrosine kinases (RTKs) and membrane-anchored ephrin
ligands critically regulate axon pathfinding and development of the cardiovascular system …