S100 is a multigenic family of non-ubiquitous Ca2+-modulated proteins of the EF-hand type
expressed in vertebrates exclusively and implicated in intracellular and extracellular …

The process by which normal cells become progressively transformed to malignancy is now
known to require the sequential acquisition of mutations which arise as a consequence of …

Background Microcell-mediated transfer of chromosome 6 into human C8161 and MelJuSo
melanoma cells suppresses their ability to metastasize by at least 95% without affecting their …

Effective methods are needed to identify and isolate those genes that are differentially
expressed in various cells or under altered conditions. This report describes a method to …

A gene encoding a protein related to the serpin family of protease inhibitors was identified
as a candidate tumor suppressor gene that may play a role in human breast cancer. The …

The Receptor for Advanced Glycation Endproducts (RAGE) is a multi-ligand receptor of the
immunoglobulin family. RAGE interacts with structurally different ligands probably through …

A multigenic family of Ca2+-binding proteins of the EF-hand type known as S100 comprises
19 members that are differentially expressed in a large number of cell types. Members of this …

The mechanisms that maintain the epithelial integrity of the gastrointestinal tract remain
largely undefined. The gene encoding intestinal trefoil factor (ITF), a protein secreted …

An inverse association has been observed between dietary intake of lycopene and the risk
of prostate cancer. We investigated the effects of lycopene supplementation in patients with …

Cytokines are soluble proteins that allow for communication between cells and the external
environment. Interferon (IFN) alpha, the first cytokine to be produced by recombinant DNA …