Ecological modelling approaches for predicting emergent properties in microbial communities

NI van den Berg, D Machado, S Santos… - Nature ecology & …, 2022 - nature.com
Recent studies have brought forward the critical role of emergent properties in shaping
microbial communities and the ecosystems of which they are a part. Emergent properties …

Reconstructing organisms in silico: genome-scale models and their emerging applications

X Fang, CJ Lloyd, BO Palsson - Nature Reviews Microbiology, 2020 - nature.com
Escherichia coli is considered to be the best-known microorganism given the large number
of published studies detailing its genes, its genome and the biochemical functions of its …

[HTML][HTML] Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine

A Heinken, J Hertel, G Acharya, DA Ravcheev… - Nature …, 2023 - nature.com
The human microbiome influences the efficacy and safety of a wide variety of commonly
prescribed drugs. Designing precision medicine approaches that incorporate microbial …

Bacillus velezensis stimulates resident rhizosphere Pseudomonas stutzeri for plant health through metabolic interactions

X Sun, Z Xu, J Xie, V Hesselberg-Thomsen… - The ISME …, 2022 - academic.oup.com
Trophic interactions play a central role in driving microbial community assembly and
function. In gut or soil ecosystems, successful inoculants are always facilitated by efficient …

Genome content predicts the carbon catabolic preferences of heterotrophic bacteria

M Gralka, S Pollak, OX Cordero - Nature Microbiology, 2023 - nature.com
Heterotrophic bacteria—bacteria that utilize organic carbon sources—are taxonomically and
functionally diverse across environments. It is challenging to map metabolic interactions and …

MEMOTE for standardized genome-scale metabolic model testing

C Lieven, ME Beber, BG Olivier, FT Bergmann… - Nature …, 2020 - nature.com
To the Editor—Reconstructing metabolic reaction networks enables the development of
testable hypotheses of an organism's metabolism under different conditions 1. State-of-the …

Metabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community

S Blasche, Y Kim, RAT Mars, D Machado… - Nature …, 2021 - nature.com
Microbial communities often undergo intricate compositional changes yet also maintain
stable coexistence of diverse species. The mechanisms underlying long-term coexistence …

[HTML][HTML] Current status and applications of genome-scale metabolic models

C Gu, GB Kim, WJ Kim, HU Kim, SY Lee - Genome biology, 2019 - Springer
Genome-scale metabolic models (GEMs) computationally describe gene-protein-reaction
associations for entire metabolic genes in an organism, and can be simulated to predict …

eQuilibrator 3.0: a database solution for thermodynamic constant estimation

ME Beber, MG Gollub, D Mozaffari… - Nucleic acids …, 2022 - academic.oup.com
Abstract eQuilibrator (equilibrator. weizmann. ac. il) is a database of biochemical equilibrium
constants and Gibbs free energies, originally designed as a web-based interface. While the …

[HTML][HTML] A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism

H Lu, F Li, BJ Sánchez, Z Zhu, G Li, I Domenzain… - Nature …, 2019 - nature.com
Genome-scale metabolic models (GEMs) represent extensive knowledgebases that provide
a platform for model simulations and integrative analysis of omics data. This study …