Epileptogenesis is defined as the process of developing epilepsy—a disorder characterized
by recurrent seizures—following an initial insult. Seizure incidence during the human …

The past decade has brought many advances in our understanding of GABA A receptor-
mediated ethanol action in the central nervous system. We now know that specific GABA A …

Temporal lobe epilepsy represents a major cause of drug-resistant epilepsy. Cognitive
impairment is a frequent comorbidity, but the mechanisms are not fully elucidated. We …

Early life seizures can result in chronic epilepsy, cognitive deficits and behavioral changes
such as autism, and conversely epilepsy is common in autistic children. We hypothesized …

Neonatal seizures are an important example of an age-specific seizure syndrome.
Compared with seizures at older ages, neonatal seizures differ in etiology, semiology, and …

Epilepsy is increasingly recognized as a disease that reaches well beyond seizures.
Cognitive and psychiatric impairment affect half of all epilepsy patients, and to date there are …

Objective: A study was undertaken to characterize the plasticity of AMPA receptor (AMPAR)‐
mediated neurotransmission in the hippocampus during status epilepticus (SE). Methods …

Abstract Calcium (Ca 2+)-permeable AMPA receptors may, in certain circumstances,
contribute to normal synaptic plasticity or to neurodegeneration. AMPA receptors are Ca 2+ …

Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be
due to a developmental increase in expression of the neuronal Na+-K+-2 Cl− cotransporter …

For several decades, both in vitro and in vivo models of seizures and epilepsy have been
employed to unravel the molecular and cellular mechanisms underlying the occurrence of …