Antischistosomal agents: state of art and perspectives

EM Lago, RP Xavier, TR Teixeira, LM Silva… - Future Medicinal …, 2018 - Taylor & Francis
Praziquantel has remained the drug of choice for schistosomiasis chemotherapy for almost
40 years. The pressing need to develop a new antischistosomal drug may necessitate …

Antischistosomal activity of ginger (Zingiber officinale) against Schistosoma mansoni harbored in C57 mice

OMS Mostafa, RA Eid, MA Adly - Parasitology Research, 2011 - Springer
The repeated chemotherapy of schistosomiasis has resulted in the emergence of drug-
resistant schistosome strains. The development of such resistance has drawn the attention …

Antischistosomal Activity of Zingiber officinale, Piper nigrum, and Coriandrum sativum Aqueous Plant Extracts on Hamster Infected with Schistosoma mansoni

MF Abou El-Nour, Y Fadladdin - Journal of Parasitology …, 2021 - Wiley Online Library
Schistosomiasis continues to affect the health and quality of life of millions of people around
the world. Schistosomiasis has been ranked the second disease after malaria in terms of …

TEGUMENTAL CHANGES IN ADULT SCHISTOSOMA MANSONI HARBORED IN MICE TREATED WITH ARTEMETHER

X Shuhua, S Binggui, J Chollet… - Journal of …, 2000 - meridian.allenpress.com
A detailed temporal examination was made of alterations induced by artemether in the
tegument of adult Schistosoma mansoni worms using scanning electron microscopy (SEM) …

Transmission electron microscopic observations on ultrastructural alterations in Schistosoma mansoni adult worms recovered from C57BL/6 mice treated with …

EA El-Shabasy, ES Reda, SH Abdeen, AE Said… - Parasitology …, 2015 - Springer
Although the current treatment of schistosomiasis relies largely on praziquantel (PZQ), it has
not been successful in significantly reducing the overall rate of disease cases, one of the …

[HTML][HTML] Ultrastructure alterations of adult male Schistosoma mansoni harbored in albino mice treated with Sidr honey and/or Nigella sativa oil

OMS Mostafa, MI Soliman - Journal of King Saud University-Science, 2010 - Elsevier
In this investigation, the effects of Sidr honey, Nigella sativa oil (black-seed oil) and Sidr
honey and black-seed oil together on the ultrastructure of tegument, gastrodermis and testes …

Effect of a novel benzimidazole derivative in experimental Schistosoma mansoni infection

SA El Bialy, A Taman, SN El-Beshbishi, B Mansour… - Parasitology …, 2013 - Springer
Currently, praziquantel is the only drug of choice for treatment of schistosomiasis. Reports of
praziquantel resistance raise concerns about future control of the disease. Therefore, the …

Triclabendazole and its two main metabolites lack activity against Schistosoma mansoni in the mouse model.

J Keiser, NA El Ela, E El Komy… - The American journal …, 2006 - europepmc.org
Some have claimed that triclabendazole, a safe and efficacious drug for the treatment of
fascioliasis, also exhibits antischistosomal properties, but results are conflicting. We …

Homology modelling, molecular dynamics simulation and docking evaluation of β-tubulin of Schistosoma mansoni

F El-Shehabi, B Mansour, WA Bayoumi, SA El Bialy… - Biophysical …, 2021 - Elsevier
Schistosomiasis is one of the neglected diseases causing considerable morbidity and
mortality throughout the world. Microtubules with its main component, tubulin play a vital role …

In vitro screening of BTP-Iso on Schistosoma mansoni and its intermediate host Biomphalaria alexandrina

A Taman, SN El-Beshbishi, S El Bardicy… - Asian Pacific Journal of …, 2016 - Elsevier
Objective To test the effect of benzimidazole-derived compound (compound BTP-Iso) on
cultured adult Schistosoma mansoni and clean Biomphalaria alexandrina snails. Methods …