Recent developments on therapeutic and diagnostic approaches for COVID-19

J Majumder, T Minko - The AAPS journal, 2021 - Springer
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a serious public health …

COVID-19 vaccines: The status and perspectives in delivery points of view

JY Chung, MN Thone, YJ Kwon - Advanced drug delivery reviews, 2021 - Elsevier
Due to the high prevalence and long incubation periods often without symptoms, the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected millions of individuals …

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

YJ Hou, S Chiba, P Halfmann, C Ehre, M Kuroda… - Science, 2020 - science.org
The spike aspartic acid–614 to glycine (D614G) substitution is prevalent in global severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but its effects on viral …

[PDF][PDF] COVID-19-neutralizing antibodies predict disease severity and survival

WF Garcia-Beltran, EC Lam, MG Astudillo, D Yang… - Cell, 2021 - cell.com
Summary Coronavirus disease 2019 (COVID-19) exhibits variable symptom severity ranging
from asymptomatic to life-threatening, yet the relationship between severity and the humoral …

[PDF][PDF] Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology

L Piccoli, YJ Park, MA Tortorici, N Czudnochowski… - Cell, 2020 - cell.com
Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-
CoV-2 infection is crucial for understanding immune protection and identifying targets for …

[PDF][PDF] Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition

AJ Greaney, TN Starr, P Gilchuk, SJ Zost, E Binshtein… - Cell host & …, 2021 - cell.com
Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being
developed as therapeutics and are a major contributor to neutralizing antibody responses …

Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19

MC Woodruff, RP Ramonell, DC Nguyen… - Nature …, 2020 - nature.com
A wide spectrum of clinical manifestations has become a hallmark of the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic, although the …

Potently neutralizing and protective human antibodies against SARS-CoV-2

SJ Zost, P Gilchuk, JB Case, E Binshtein, RE Chen… - Nature, 2020 - nature.com
The ongoing pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major threat to global health …

[PDF][PDF] Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

N Suryadevara, S Shrihari, P Gilchuk, LA VanBlargan… - Cell, 2021 - cell.com
Most human monoclonal antibodies (mAbs) neutralizing SARS-CoV-2 recognize the spike
(S) protein receptor-binding domain and block virus interactions with the cellular receptor …

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

PA Koenig, H Das, H Liu, BM Kümmerer, FN Gohr… - Science, 2021 - science.org
INTRODUCTION The global scale and rapid spread of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) pose unprecedented challenges to society, health care …