Adrenergic receptors (AR) are G-protein-coupled receptors (GPCRs) that have a crucial role in cardiac physiology in health and disease. Alpha 1-ARs signal through Gα q, and signaling …
BC Calzada, AA de Artiñano - Pharmacological research, 2001 - Elsevier
Different studies have led to our present knowledge of the membrane receptors responsible for mediating the responses to the endogenous catecholamines. These receptors were …
The a, ARs are important mediators of sympathetic nervous system responses, particularly those involved in cardiovascular homeostasis, such as arteriolar smooth muscle constriction …
The technique of in situ hybridization with specific ribonucleotide probes was used to determine the distribution patterns of mRNA encoding the α1a-, α1b-and α1d-adrenoceptor …
H Zhong, KP Minneman - European journal of pharmacology, 1999 - Elsevier
α1-Adrenoceptors are one of three subfamilies of receptors (α1, α2, β) mediating responses to adrenaline and noradrenaline. Three α1-adrenoceptor subtypes are known (α1A, α1B …
JN Palmer, WE Hartogensis, M Patten… - The Journal of …, 1995 - Am Soc Clin Investig
Interleukin-1 (IL-1), initially called" endogenous pyrogen," is primarily known as a mediator of inflammation. However, it also plays many other diverse physiologic roles including the …
DG Rokosh, PC Simpson - Proceedings of the National …, 2002 - National Acad Sciences
α1-adrenergic receptors (ARs) play a major role in blood pressure regulation. The three α1- AR subtypes (A/C, B, and D) stimulate contraction of isolated arteries, but it is uncertain how …
MC Michel, B Kenny, DA Schwinn - Naunyn-Schmiedeberg's archives of …, 1995 - Springer
Two α 1-adrenoceptor subtypes (α 1A and α 1B) have been detected in various tissues by pharmacological techniques, and three distinct cDNAs encoding α 1-adrenoceptor subtypes …
Alpha-1–adrenergic receptors (ARs) are G protein–coupled receptors activated by catecholamines. The alpha-1A and alpha-1B subtypes are expressed in mouse and human …