In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …

Glycosylation, the addition of glycans or carbohydrates to proteins, lipids, or other glycans, is
a complex post-translational modification that plays a crucial role in cellular function. It is …

Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

Histones display a wide variety of post-translational modifications, including acetylation,
methylation, and phosphorylation. These epigenetic modifications can influence chromatin …

The central dogma of molecular genetics is defined as encoded genetic information within
DNA, transcribed into messenger RNA, which contain the instructions for protein synthesis …

Cellular identity in multicellular organisms is maintained by characteristic transcriptional
networks, nutrient consumption, energy production and metabolite utilization. Integrating …

Aerobic exercise is well known to promote neuroplasticity and hippocampal memory. In the
developing brain, early-life exercise (ELE) can lead to persistent improvements in …

O-linked-β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification (PTM) that is
actively added to and removed from thousands of intracellular proteins. As a PTM, O …

Humans have known for millennia that nutrition has a profound influence on health and
disease, but it is only recently that we have begun mapping the mechanisms via which the …

Hypocalcemia, associated with Calcium neurotoxicity, has been reported to induce nerve
dysfunction, which is a significant problem of renal failure. This study identifies a molecular …