Systemic sclerosis, also called scleroderma, is an immune-mediated rheumatic disease that
is characterised by fibrosis of the skin and internal organs and vasculopathy. Although …

Raynaud phenomenon is a symptom complex caused by impaired digital perfusion and can
occur as a primary phenomenon or secondary to a wide range of underlying causes …

The aim was to update the 2009 European League against Rheumatism (EULAR)
recommendations for the treatment of systemic sclerosis (SSc), with attention to new …

Objective There is a lack of agreement regarding treatment for many aspects of systemic
sclerosis (SS c). We undertook this study to generate SS c treatment algorithms endorsed by …

Pemphigus is a group of rare, potentially devastating autoimmune diseases of the skin and
mucous membranes with high morbidity and potentially lethal outcome. The major clinical …

Raynaud’s Phenomenon | New England Journal of Medicine Skip to main content The New
England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …

Systemic sclerosis (SSc) has the highest cause-specific mortality of all the connective tissue
diseases, and the aetiology of this complex and heterogeneous condition remains an …

Discovered in 1987 as a potent endothelial cell–derived vasoconstrictor peptide, endothelin-
1 (ET-1), the predominant member of the endothelin peptide family, is now recognized as a …

The endothelin axis, recognized for its vasoconstrictive action, plays a central role in the
pathology of pulmonary arterial hypertension (PAH). Treatment with approved endothelin …

There are two major clinical subsets of scleroderma:(i) systemic sclerosis (SSc) is a complex
systemic autoimmune disorder characterized by inflammation, vasculopathy, and excessive …