Abstract CD4+ T helper (Th) cells are critical for proper immune cell homeostasis and host
defense, but are also major contributors to pathology of autoimmune and inflammatory …

Myasthenia gravis (MG) is an acquired neurological autoimmune disorder characterized by
dysfunctional transmission at the neuromuscular junction, with its etiology associated with …

We describe de novo generation of IL-17-producing T cells from naive CD4 T cells, induced
in cocultures of naive CD4 T cells and naturally occurring CD4+ CD25+ T cells (Treg) in the …

Background and aim: Interleukin (IL) 17 is a cytokine which exerts strong proinflammatory
activities. In this study we evaluated changes in IL-17 expression in the inflamed mucosa …

We have characterized a cytokine produced by Th2 cells, designated as IL-25. Infusion of
mice with IL-25 induced IL-4, IL-5, and IL-13 gene expression. The induction of these …

Uncontrolled mucosal immunity in the gastrointestinal tract of humans results in chronic
inflammatory bowel disease (IBD), such as Crohn disease and ulcerative colitis. In early …

Abstract Interleukin-17 (IL-17) is a proinflammatory cytokine produced by T cells. The
involvement of IL-17 in human diseases has been suspected because of its detection in sera …

IL-17 is a potent proinflammatory cytokine produced by activated memory T cells. The large-
scale sequencing of the human and other vertebrate genomes has revealed the presence of …

IL-17-producing T cells have recently been classified as a new effector T-cell subset, termed
Th17, which is distinct from Th1, Th2 and Treg subsets. There has been much progress in …

We have biologically characterized two new members of the IL-17 cytokine family: IL-17F
and IL-25. In contrast to conventional in vitro screening approaches, we have characterized …