Metabolic adaptations in cancer stem cells

UP Yadav, T Singh, P Kumar, P Sharma, H Kaur… - Frontiers in …, 2020 - frontiersin.org
Cancer stem cells (CSCs) are a small and elusive subpopulation of self-renewing cancer
cells with remarkable ability to initiate, propagate, and spread the malignant disease. In …

On the origin of ATP synthesis in cancer

TN Seyfried, G Arismendi-Morillo, P Mukherjee… - Iscience, 2020 - cell.com
ATP is required for mammalian cells to remain viable and to perform genetically
programmed functions. Maintenance of the ΔG′ ATP hydrolysis of− 56 kJ/mole is the …

Mitochondrial substrate-level phosphorylation as energy source for glioblastoma: review and hypothesis

C Chinopoulos, TN Seyfried - ASN neuro, 2018 - journals.sagepub.com
Glioblastoma multiforme (GBM) is the most common and malignant of the primary adult brain
cancers. Ultrastructural and biochemical evidence shows that GBM cells exhibit …

Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma

P Mukherjee, ZM Augur, M Li, C Hill… - Communications …, 2019 - nature.com
Glioblastoma (GBM) is an aggressive primary human brain tumour that has resisted effective
therapy for decades. Although glucose and glutamine are the major fuels that drive GBM …

Can the mitochondrial metabolic theory explain better the origin and management of cancer than can the somatic mutation theory?

TN Seyfried, C Chinopoulos - Metabolites, 2021 - mdpi.com
A theory that can best explain the facts of a phenomenon is more likely to advance
knowledge than a theory that is less able to explain the facts. Cancer is generally …

Consideration of ketogenic metabolic therapy as a complementary or alternative approach for managing breast cancer

TN Seyfried, P Mukherjee, MS Iyikesici, A Slocum… - Frontiers in …, 2020 - frontiersin.org
Breast cancer remains as a significant cause of morbidity and mortality in women.
Ultrastructural and biochemical evidence from breast biopsy tissue and cancer cells shows …

Beyond mitochondria: Alternative energy-producing pathways from all strata of life

C Auger, R Vinaik, VD Appanna, MG Jeschke - Metabolism, 2021 - Elsevier
It is well-established that mitochondria are the powerhouses of the cell, producing
adenosine triphosphate (ATP), the universal energy currency. However, the most significant …

Role of mycoplasma chaperone DnaK in cellular transformation

F Benedetti, F Cocchi, OS Latinovic, S Curreli… - International Journal of …, 2020 - mdpi.com
Studies of the human microbiome have elucidated an array of complex interactions between
prokaryotes and their hosts. However, precise bacterial pathogen–cancer relationships …

Succinate: a novel mediator to promote atherosclerotic lesion progression

S Zhang, Y Liang, L Li, Y Chen, P Wu… - DNA and Cell Biology, 2022 - liebertpub.com
Succinate is an important intermediate product of mitochondrial energy metabolism. Recent
studies revealed that beyond its known traditional metabolic functions, succinate plays …

Metabolic management of microenvironment acidity in glioblastoma

TN Seyfried, G Arismendi-Morillo, G Zuccoli… - Frontiers in …, 2022 - frontiersin.org
Glioblastoma (GBM), similar to most cancers, is dependent on fermentation metabolism for
the synthesis of biomass and energy (ATP) regardless of the cellular or genetic …