Metabolic engineering is the science of rewiring the metabolism of cells to enhance
production of native metabolites or to endow cells with the ability to produce new products …

Bacteria exist as communities in diverse multispecies environments. Quorum sensing, a
process for cell–cell communication, allows individual bacteria to glean information about …

Metabolic engineering of microorganisms to produce desirable products on an industrial
scale can result in unbalanced cellular metabolic networks that reduce productivity and …

Global energy demand and environmental concerns have stimulated increasing efforts to
produce carbon-neutral fuels directly from renewable resources. Microbially derived …

Intercellular signaling is indispensable for single cells to form complex biological structures,
such as biofilms, tissues and organs. The genetic tools available for engineering …

The power of a single engineered organism is limited by its capacity for genetic modification.
To circumvent the constraints of any singular microbe, a new frontier in synthetic biology is …

Highlights•Rational and modern approaches for metabolic pathway engineering.•Tailor-
made cell factories for biofuel and value-added chemical production.•Synthetic and systems …

Metabolic engineering strategies have enabled improvements in yield and titer for a variety
of valuable small molecules produced naturally in microorganisms, as well as those …

Terpenoids, also called isoprenoids, are a large and highly diverse family of natural
products with important medical and industrial properties. However, a limited production of …

Quorum sensing (QS) is a ubiquitous cell–cell communication mechanism that can be
employed to autonomously and dynamically control metabolic fluxes. However, since the …