Transforming growth factor-beta (TGF-β) signaling is one of the important cellular pathways
that play key roles for tissue maintenance. In particular, it is important in the context of …

The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed more
than a decade ago. Since then, the concept of how the TGFβ signal travels from the …

The intestinal epithelium possesses a remarkable self-renewal ability, which is mediated by
actively proliferating Lgr5+ stem cells. Bone morphogenetic protein (BMP) signalling …

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease where invasive
pulmonary myofibroblasts secrete collagen and destroy lung integrity. Here, we show that …

The genetic changes leading to the development of human cancer are accompanied by
alterations in the structure and modification status of chromatin, which represent powerful …

The abilities of stem cells to self-renew and form different mature cells expand the
possibilities of applications in cell-based therapies such as tissue recomposition in …

Growth factors and mechanical cues synergistically affect cellular functions, triggering a
variety of signaling pathways. The molecular levels of such cooperative interactions are not …

Embryonic stem cells (ESCs) can be maintained in culture indefinitely while retaining the
capacity to generate any type of cell in the body, and therefore not only hold great promise …

Dysregulated bone morphogenetic protein (BMP) signaling in endothelial cells (ECs) and
pulmonary arterial smooth muscle cells (PASMCs) are implicated in human genetic …

Ligands of the TGF-β superfamily (including the TGF-βs, Nodal and BMPs) play instructive
roles during embryonic development. This is achieved by regulation of genes important for …