Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has attracted
attention from several viewpoints of basic and translational research. Its cell cycle-regulated …

Molecules that can specifically silence gene expression are powerful research tools. Much
effort has been put into the development of such molecules and has resulted in the creation …

Survivin is a 16.5 kDa protein overexpressed in almost all malignancies but rarely detected
in normal differentiated adult tissues. Functionally, survivin has been shown to inhibit …

Different diagnostic and prognostic groups of colorectal carcinoma (CRC) have been
defined. However, accurate diagnosis and prediction of survival are sometimes difficult …

Abstract Background MicroRNAs (MiRNAs) are short non-coding RNAs that control protein
expression through various mechanisms. Their altered expression has been shown to be …

Apoptosis levels have been shown to predict tumor response to preoperative
radiochemotherapy in rectal cancer. Recently, the prominent role of survivin, a structurally …

Since programmed cell death was first described by the electron microscopic cellular
changes demonstrating an organized form of cell death over 30 years ago, it has undergone …

With the development of RNA interference (RNAi) libraries, systematic and cost-effective
genome-wide loss-of-function screens can now be carried out with the aim of assessing the …

While in multicellular organisms all cells inexorably die, there are several different ways
provided for the realization of cell death. One of them, apoptosis, represents a universal …

Killing of tumor cells by anticancer therapies commonly used in the treatment of cancer, eg
chemotherapy, γ-irradiation, immunotherapy or suicide gene therapy, is predominantly …