Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Biointerface design for vertical nanoprobes

R Elnathan, MG Barbato, X Guo, A Mariano… - Nature Reviews …, 2022 - nature.com
Biointerfaces mediate safe and efficient cell manipulation, which is essential for biomedical
innovations in advanced therapies and diagnostics. The biointerface established by vertical …

High‐aspect‐ratio nanostructured surfaces as biological metamaterials

SG Higgins, M Becce… - Advanced …, 2020 - Wiley Online Library
Materials patterned with high‐aspect‐ratio nanostructures have features on similar length
scales to cellular components. These surfaces are an extreme topography on the cellular …

Tutorial: using nanoneedles for intracellular delivery

C Chiappini, Y Chen, S Aslanoglou, A Mariano… - Nature …, 2021 - nature.com
Intracellular delivery of advanced therapeutics, including biologicals and supramolecular
agents, is complex because of the natural biological barriers that have evolved to protect the …

Porous silicon nanoneedles modulate endocytosis to deliver biological payloads

S Gopal, C Chiappini, J Penders… - Advanced …, 2019 - Wiley Online Library
Owing to their ability to efficiently deliver biological cargo and sense the intracellular milieu,
vertical arrays of high aspect ratio nanostructures, known as nanoneedles, are being …

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

L Chen, S Zhang, Y Duan, X Song, M Chang… - Chemical Society …, 2024 - pubs.rsc.org
The invention of silica-based bioactive glass in the late 1960s has sparked significant
interest in exploring a wide range of silicon-containing biomaterials from the macroscale to …

A comprehensive review on intracellular delivery

D Morshedi Rad, M Alsadat Rad… - Advanced …, 2021 - Wiley Online Library
Intracellular delivery is considered an indispensable process for various studies, ranging
from medical applications (cell‐based therapy) to fundamental (genome‐editing) and …

Nanoneedle platforms: the many ways to pierce the cell membrane

G He, N Hu, AM Xu, X Li, Y Zhao… - Advanced functional …, 2020 - Wiley Online Library
Establishing techniques to efficiently and nondestructively access the intracellular milieu is
essential for many biomedical and scientific applications, ranging from drug delivery, to …

High throughput and highly controllable methods for in vitro intracellular delivery

J Brooks, G Minnick, P Mukherjee, A Jaberi, L Chang… - Small, 2020 - Wiley Online Library
In vitro and ex vivo intracellular delivery methods hold the key for releasing the full potential
of tissue engineering, drug development, and many other applications. In recent years, there …

Interfacing cells with vertical nanoscale devices: applications and characterization

AF McGuire, F Santoro, B Cui - Annual Review of Analytical …, 2018 - annualreviews.org
Measurements of the intracellular state of mammalian cells often require probes or
molecules to breach the tightly regulated cell membrane. Mammalian cells have been …