Early-onset colorectal cancer: initial clues and current views
Over the past several decades, the incidence of early-onset colorectal cancer (EOCRC; in
patients< 50 years old) has increased at an alarming rate. Although robust and scientifically …
patients< 50 years old) has increased at an alarming rate. Although robust and scientifically …
Primary immunodeficiency and autoimmunity: a comprehensive review
The primary immunodeficiency diseases (PIDs) include many genetic disorders that affect
different components of the innate and adaptive responses. The number of distinct genetic …
different components of the innate and adaptive responses. The number of distinct genetic …
Urbanization and the gut microbiota in health and inflammatory bowel disease
In the 21st century, urbanization represents a major demographic shift in developed and
developing countries. Rapid urbanization in the developing world has been associated with …
developing countries. Rapid urbanization in the developing world has been associated with …
IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM
JR Catanzaro, JD Strauss, A Bielecka, AF Porto… - Scientific reports, 2019 - nature.com
Immunoglobulin A is the dominant antibody isotype found in mucosal secretions and
enforces host-microbiota symbiosis in mice, yet selective IgA-deficiency (sIgAd) in humans is …
enforces host-microbiota symbiosis in mice, yet selective IgA-deficiency (sIgAd) in humans is …
Human RAG mutations: biochemistry and clinical implications
The recombination-activating gene 1 (RAG1) and RAG2 proteins initiate the V (D) J
recombination process, which ultimately enables the generation of T cells and B cells with a …
recombination process, which ultimately enables the generation of T cells and B cells with a …
Vertically transferred maternal immune cells promote neonatal immunity against early life infections
IA Stelzer, C Urbschat, S Schepanski, K Thiele… - Nature …, 2021 - nature.com
During mammalian pregnancy, immune cells are vertically transferred from mother to fetus.
The functional role of these maternal microchimeric cells (MMc) in the offspring is mostly …
The functional role of these maternal microchimeric cells (MMc) in the offspring is mostly …
IgA function in relation to the intestinal microbiota
AJ Macpherson, B Yilmaz, JP Limenitakis… - Annual review of …, 2018 - annualreviews.org
IgA is the dominant immunoglobulin isotype produced in mammals, largely secreted across
the intestinal mucosal surface. Although induction of IgA has been a hallmark feature of …
the intestinal mucosal surface. Although induction of IgA has been a hallmark feature of …
Specialization of mucosal immunoglobulins in pathogen control and microbiota homeostasis occurred early in vertebrate evolution
Although mammalian secretory immunoglobulin A (sIgA) targets mucosal pathogens for
elimination, its interaction with the microbiota also enables commensal colonization and …
elimination, its interaction with the microbiota also enables commensal colonization and …
RAG deficiency: two genes, many diseases
Purpose To review the clinical and laboratory spectrum of RAG gene defects in humans, and
discuss the mechanisms underlying phenotypic heterogeneity, the basis of immune …
discuss the mechanisms underlying phenotypic heterogeneity, the basis of immune …
Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells
K Csomos, B Ujhazi, P Blazso, JL Herrera… - Nature …, 2022 - nature.com
The recombination-activating genes (RAG) 1 and 2 are indispensable for diversifying the
primary B cell receptor repertoire and pruning self-reactive clones via receptor editing in the …
primary B cell receptor repertoire and pruning self-reactive clones via receptor editing in the …