β-arrestin1 (or arrestin2) and β-arrestin2 (or arrestin3) are ubiquitously expressed cytosolic
adaptor proteins that were originally discovered for their inhibitory role in G protein–coupled …

Although long regarded as a conduit for the degradation or recycling of cell surface
receptors, the endosomal system is also an essential site of signal transduction. Activated …

Trace amine-associated receptor 1 (TAAR1) activation by selective endogenous agonists
modulates dopaminergic neurotransmission. This results in antipsychotic-like behavior in …

Over the last decade β-arrestins have emerged as pleiotropic scaffold proteins, capable of
mediating numerous diverse responses to multiple agonists. Most well characterized are the …

Abundant evidences have shown that ghrelin, by its binding to GHS-R1a, plays an important
role for fundamental physiological functions. Increasing attention is given to the GHS-R1a …

The insulin/insulin-like growth factor (IGF)-1 signaling pathway (ISP) plays a fundamental
role in long term health in a range of organisms. Protein kinases including Akt and ERK are …

The β-arrestins (β-arrs) were initially appreciated for the roles they play in the
desensitization and endocytosis of G protein-coupled receptors (GPCRs). They are now also …

Background The purpose of this study was to examine the in vivo activity of rosmarinic acid
(RA)–a phytochemical with antioxidant, anti-inflammatory, and antiviral properties–against …

Abstract Protein tyrosine kinase 6 (PTK6) is a nonmyristoylated Src-related intracellular
tyrosine kinase. Although not expressed in the normal mammary gland, PTK6 is expressed …

Purpose: c-Src inhibition in cancer cells leads to an abrogation of invasion but a variable
effect on apoptosis. The pathways downstream of c-Src promoting survival are not well …