Since material stiffness controls many cell functions, we reviewed the currently available
knowledge on stiffness sensing and elucidated what is known in the context of clinical and …

Mechanical loading is essential for chondrocyte health. Chondrocytes can sense and
respond to various extracellular mechanical signals through an integrated set of …

OBJECTIVE: To determine whether the functional properties of tissue-engineered constructs
cultured in a chemically-defined medium supplemented briefly with TGF-β3 can be …

A new method for encapsulating cells in interpenetrating network (IPN) hydrogels of superior
mechanical integrity was developed. In this study, two biocompatible materials—agarose …

Poor regenerative potential of cartilage tissue due to the avascular nature and lack of
supplementation of reparative cells impose an important challenge in recent medical …

Numerous studies have assembled a complex picture, in which extracellular stimuli and
intracellular signaling pathways modulate the chondrocyte phenotype. Because many …

The cytoskeleton of all cells is a three‐dimensional network comprising actin microfilaments,
tubulin microtubules and intermediate filaments. Studies in many cell types have indicated …

Mechanical factors play a key role in regulating the development of cartilage degradation in
osteoarthritis. This study aimed to identify the influence of mechanical stress in cartilage and …

Efficient ex vivo methods for expanding primary human chondrocytes while maintaining the
phenotype is critical to advancing the sourcing of autologous cells for tissue engineering …

The way in which the nucleus experiences mechanical forces has important implications for
understanding mechanotransduction. Knowledge of nuclear material properties and …