In bone regenerative medicine there is a need for suitable bone substitutes. Hydrogels have
excellent biocompatible and biodegradable characteristics, but their visco-elastic properties …

Skeletal stem cells (SSCs) that are the major source of osteoblasts and adipocytes in adult
bone marrow express leptin receptor (LepR). To test whether LepR regulates SSC function …

Skeletal aging is a complex process, characterized by a decrease in bone formation, an
increase in marrow fat, and stem cell exhaustion. Loss of H3K9me3, a heterochromatin …

We previously showed that Irisin, a myokine released from skeletal muscle after physical
exercise, plays a central role in the control of bone mass. Here we report that treatment with …

Skeletal stem cells (SSCs) are postulated to provide a continuous supply of osteoblasts
throughout life. However, under certain conditions, the SSC population can become …

The ability to print defined patterns of cells and extracellular‐matrix components in three
dimensions has enabled the engineering of simple biological tissues; however, bioprinting …

Calcium phosphate (CaP) scaffolds with three-dimensionally-interconnected pores play an
important role in mechanical interlocking and biological fixation in bone implant …

Bone marrow derived mesenchymal progenitor cells (MPCs) play an important role in bone
homeostasis. Age-related changes occur in bone resulting in a decrease in bone density …

Long bone fractures are one of the most common and costly medical conditions
encountered after trauma. Characterization of the biology of fracture healing and …

Abstract PI3K/AKT is one of the key pathways that regulate cell behaviors including
apoptosis, proliferation, and differentiation. Although previous studies have demonstrated …