The regulative capability of single cells to give rise to all primary embryonic lineages is
termed pluripotency. Observations of fluctuating gene expression and phenotypic …

Specific cells within the early mammalian embryo have the capacity to generate all somatic
lineages plus the germline. This property of pluripotency is confined to the epiblast, a …

Current human pluripotent stem cells lack the transcription factor circuitry that governs the
ground state of mouse embryonic stem cells (ESC). Here, we report that short-term …

Mouse epiblast stem cells (EpiSCs) can be derived from a wide range of developmental
stages. To characterize and compare EpiSCs with different origins, we derived a series of …

During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the
three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo …

Pluripotent cells in the mammalian embryo undergo state transitions marked by changes in
patterns of gene expression and developmental potential as they progress from pre …

During gastrulation, epiblast cells are pluripotent and their fate is thought to be constrained
principally by their position. Cell fate is progressively restricted by localised signalling cues …

Self‐renewal of pluripotent mouse embryonic stem (ES) cells is sustained by the cytokine
leukaemia inhibitory factor (LIF) acting through the transcription factor Stat3. Several targets …

Though totipotency and pluripotency are transient during early embryogenesis, they
establish the foundation for the development of all mammals. Studying these in vivo has …

The peri-implantation window of mammalian development is the crucial window for
primordial germ cell (PGC) specification. Whereas pre-implantation dynamics are relatively …